Selection of Antibody Responses Associated With Plasmodium falciparum Infections in the Context of Malaria Elimination.

ABSTRACT: In our aim to eliminate malaria, more sensitive tools to detect residual transmission are quickly becoming essential. Antimalarial antibody responses persist in the blood after a malaria infection and provide a wider window to detect exposure to infection compared to parasite detection metrics. Here, we aimed to select antibody responses associated with recent and cumulative exposure to malaria using cross-sectional survey data from Haiti, an elimination setting. Using a multiplex bead assay, we generated data for antibody responses (immunoglobulin G) to 23 Plasmodium falciparum targets in 29,481 participants across three surveys. This included one community-based survey in which participants were enrolled during household visits and two sentinel group surveys in which participants

SUBMITTER: van den Hoogen LL 

PROVIDER: S-EPMC7243477 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature