Evaluation of Clinically Meaningful Changes in Measures of Frailty.

ABSTRACT:

Background

To determine the clinically meaningful changes and responsiveness of widely used frailty measures.

Methods

We analyzed data from a prospective cohort study of 1,135 community-dwelling older adults who underwent assessments of frailty and health-related quality of life using the EuroQol-5D at baseline and 1 year later. Frailty measures included deficit-accumulation frailty index (FI); frailty phenotype; Fatigue, Resistance, Ambulation, Illness, and Loss of Weight scale; and the Study of Osteoporotic Fracture (SOF) index. We determined the clinically meaningful changes by the distribution-based method and the anchor-based method using the EuroQol-5D score and responsiveness indices.

Results

Frailty measures were available in 925 participants at 1 year (81.5%)

SUBMITTER: Jang IY 

PROVIDER: S-EPMC7243580 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature