Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles following HIV Envelope Immunization.
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ABSTRACT:
SUBMITTER: Han Q
PROVIDER: S-EPMC7243677 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles following HIV Envelope Immunization.
Han Qifeng Q Bradley Todd T Williams Wilton B WB Cain Derek W DW Montefiori David C DC Saunders Kevin O KO Parks Robert J RJ Edwards Regina W RW Ferrari Guido G Mueller Olaf O Shen Xiaoying X Wiehe Kevin J KJ Reed Steven S Fox Christopher B CB Rountree Wes W Vandergrift Nathan A NA Wang Yunfei Y Sutherland Laura L LL Santra Sampa S Moody M Anthony MA Permar Sallie R SR Tomaras Georgia D GD Lewis Mark G MG Van Rompay Koen K A KKA Haynes Barton F BF
Cell reports 20200201 5
HIV-1-infected infants develop broadly neutralizing antibodies (bnAbs) more rapidly than adults, suggesting differences in the neonatal versus adult responses to the HIV-1 envelope (Env). Here, trimeric forms of HIV-1 Env immunogens elicit increased gp120- and gp41-specific antibodies more rapidly in neonatal macaques than adult macaques. Transcriptome analyses of neonatal versus adult immune cells after Env vaccination reveal that neonatal macaques have higher levels of the apoptosis regulator ...[more]
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