High-Throughput Task to Study Memory Recall During Spatial Navigation in Rodents.

ABSTRACT: Spatial navigation is one of the most frequently used behavioral paradigms to study memory formation in rodents. Commonly used tasks to study memory are labor-intensive, preventing the simultaneous testing of multiple animals with the tendency to yield a low number of trials, curtailing the statistical power. Moreover, they are not tailored to be combined with neurophysiology recordings because they are not based on overt stereotyped behavioral responses that can be precisely timed. Here we present a novel task to study long-term memory formation and recall during spatial navigation. The task consists of learning sessions during which mice need to find the rewarding port that changes from day to day. Hours after learning, there is a recall session during which mice search for the location

SUBMITTER: Morales L 

PROVIDER: S-EPMC7243682 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature