The association of EGF rs2237051 variant, serum EGF levels and generalized aggressive periodontitis: a preliminary study.

ABSTRACT:

Background

Epidermal growth factor (EGF) is a pro-inflammatory small peptide that stimulates cell growth, proliferation and differentiation through binding to its receptor. EGF rs2237051 and serum EGF levels have been demonstrated to be related with a variety of diseases, including several tumors and inflammatory diseases. Therefore, this study aims to investigate the association of the EGF rs2237051 variant and serum EGF levels in Chinese patients with generalized aggressive periodontitis (GAgP).

Material and methods

A case-control study was conducted among 216 patients with GAgP and 138 healthy controls. The clinical parameters of plaque index, probing depth, attachment loss and bleeding index were recorded. The EGF rs2237051 polymorphism was genotyped

SUBMITTER: Wang X 

PROVIDER: S-EPMC7243814 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature