Airway Epithelial Cell Immunity Is Delayed During Rhinovirus Infection in Asthma and COPD.

ABSTRACT: Respiratory viral infections, particularly those caused by rhinovirus, exacerbate chronic respiratory inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Airway epithelial cells are the primary site of rhinovirus replication and responsible of initiating the host immune response to infection. Numerous studies have reported that the anti-viral innate immune response (including type I and type III interferon) in asthma is less effective or deficient leading to the conclusion that epithelial innate immunity is a key determinant of disease severity during a rhinovirus induced exacerbation. However, deficient rhinovirus-induced epithelial interferon production in asthma has not always been observed. We hypothesized that disparate in vitro airway epithe

SUBMITTER: Veerati PC 

PROVIDER: S-EPMC7243842 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature