A novel method for calculating mean erythrocyte age using erythrocyte creatine.

ABSTRACT: Estimating the lifespan of erythrocytes is useful for the differential diagnosis of anemia. However, measuring the lifespan of erythrocytes was very difficult; therefore, it was seldom measured. Erythrocyte creatine (EC) decreases reflecting erythrocyte age. We developed a method to obtain mean erythrocyte age (M_RBC) from EC.We reanalyzed the previously published data from 21 patients with hemolytic anemia, which included EC and the half-life of ⁵¹Cr.M_RBC and log_e EC showed excellent significant linearity (r = -0.9475, p < 0.001), proving that it could be treated as a mono-exponential relationship within the studied range (EC: 1.45 - 11.76 μmol/g Hb). We established an equation to obtain

SUBMITTER: Kameyama M 

PROVIDER: S-EPMC7244067 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature