Association of tumor growth rates with molecular biomarker status: a longitudinal study of high-grade glioma.

ABSTRACT: To determine the association of molecular biomarkers with tumor growth in patients with high-grade gliomas (HGGs), the tumor growth rates and molecular biomarker status in 109 patients with HGGs were evaluated. Mean tumor diameter was assessed on at least two pre-surgical T₂-weighted and contrast-enhancement T_1-weighted magnetic resonance images (MRIs). Tumor growth rates were calculated based on tumor volume and diameter using various methods. The association of biomarkers with increased or decreased tumor growth was calculated using linear mixed-effects models. HGGs exhibited rapid growth rates, with an equivalent volume doubling time of 63.4 days and an equivalent velocity of diameter expansion of 51.6 mm/year. The WHO grade was an independent clinical factor of eV

SUBMITTER: Fan Z 

PROVIDER: S-EPMC7244074 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature