Urinary metabolites associate with the rate of kidney function decline in patients with autosomal dominant polycystic kidney disease.

ABSTRACT:

Background

The variable course of autosomal dominant polycystic kidney disease (ADPKD), and the advent of renoprotective treatment require early risk stratification. We applied urinary metabolomics to explore differences associated with estimated glomerular filtration rate (eGFR; CKD-EPI equation) and future eGFR decline.

Methods

Targeted, quantitative metabolic profiling (1H NMR-spectroscopy) was performed on baseline spot urine samples obtained from 501 patients with ADPKD. The discovery cohort consisted of 338 patients (56% female, median values for age 46 [IQR 38 to 52] years, eGFR 62 [IQR 45 to 85] ml/min/1.73m2, follow-up time 2.5 [range 1 to 3] years, and annual eGFR slope -3.3 [IQR -5.3 to -1.3] ml/min/1.73m2/year). An independent cohort (n = 163) was used for valida

SUBMITTER: Dekker SEI 

PROVIDER: S-EPMC7244119 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature