The membrane receptors that appeared before their ligand: The different proposed scenarios.

ABSTRACT: The interactions between membrane receptors and their endogenous ligands are key interactions in organisms. Recently, we have shown that a high number of genes encoding human receptors appeared at the same moment as their ligand in the animal tree of life. However, a set of receptors appeared before their present ligand. Different scenarios have been proposed to explain how a receptor can be conserved if its ligand is not yet appeared. However, these scenarios have been proposed individually and have never been studied in a global way. In this study, we investigated 30 mammalian pairs of ligand/receptor for which the first ligand appeared after its receptor in the tree of life, by using common indexes of selection, and proposed different scenarios explaining the earlier appearance of a rec

SUBMITTER: Grandchamp A 

PROVIDER: S-EPMC7244123 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature