Airway mir-155 responses are associated with TH1 cytokine polarization in young children with viral respiratory infections.

ABSTRACT: BACKGROUND:MicroRNAs (miRs) control gene expression and the development of the immune system and antiviral responses. MiR-155 is an evolutionarily-conserved molecule consistently induced during viral infections in different cell systems. Notably, there is still an unresolved paradox for the role of miR-155 during viral respiratory infections. Despite being essential for host antiviral TH1 immunity, miR-155 may also contribute to respiratory disease by enhancing allergic TH2 responses and NFkB-mediated inflammation. The central goal of this study was to define how airway miR-155 production is related to TH1, TH2, and pro-inflammatory cytokine responses during naturally occurring viral respiratory infections in young children. METHODS:Normalized nasal airway levels of miR-155 and nasal prote

SUBMITTER: Arroyo M 

PROVIDER: S-EPMC7244143 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature