Extracellular pH mapping of liver cancer on a clinical 3T MRI scanner.

ABSTRACT:

Purpose

To demonstrate feasibility of developing a noninvasive extracellular pH (pH_e ) mapping method on a clinical MRI scanner for molecular imaging of liver cancer.

Methods

In vivo pH_e mapping has been demonstrated on preclinical scanners (e.g., 9.4T, 11.7T) with Biosensor Imaging of Redundant Deviation in Shifts (BIRDS), where the pH_e readout by 3D chemical shift imaging (CSI) depends on hyperfine shifts emanating from paramagnetic macrocyclic chelates like TmDOTP^5- which upon extravasation from blood resides in the extracellular space. We implemented BIRDS-based pH_e mapping on a clinical 3T Siemens scanner, where typically diamagnetic ¹ H signals are detected using millisecond-long radiofrequency (RF) puls

SUBMITTER: Coman D 

PROVIDER: S-EPMC7244229 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature