A 5-Gene Stemness Score for Rapid Determination of Risk in Multiple Myeloma.

ABSTRACT:

Purpose

Risk stratification in patients with multiple myeloma (MM) remains a challenge. As clinicopathological characteristics have been demonstrated insufficient for exactly defining MM risk, and molecular biomarkers have become the focuses of interests. Prognostic predictions based on gene expression profiles (GEPs) have been the most accurate to this day. The purpose of our study was to construct a risk score based on stemness genes to evaluate the prognosis in MM.

Materials and methods

Bioinformatics studies by ingenuity pathway analyses in side population (SP) and non-SP (MP) cells of MM patients were performed. Firstly, co-expression network was built to confirm hub genes associated with the top five Kyoto Encyclopedia of Genes and Genomes pathways. Functional a

SUBMITTER: Bai H 

PROVIDER: S-EPMC7244240 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature