Ontology highlight
ABSTRACT:
SUBMITTER: Vernet N
PROVIDER: S-EPMC7244263 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Science advances 20200522 21
Gametes are generated through a specialized cell differentiation process, meiosis, which, in ovaries of most mammals, is initiated during fetal life. All-<i>trans</i> retinoic acid (ATRA) is considered as the molecular signal triggering meiosis initiation. In the present study, we analyzed female fetuses ubiquitously lacking all ATRA nuclear receptors (RAR), obtained through a tamoxifen-inducible cre recombinase-mediated gene targeting approach. Unexpectedly, mutant oocytes robustly expressed me ...[more]