Upregulation of Piezo1 Is a Novel Prognostic Indicator in Glioma Patients.

ABSTRACT:

Purpose

Previous study reported that Piezo1 was highly expressed in glioma and promoted the proliferation of glioma cells, suggesting that Piezo1 overexpression might contribute to the poor prognosis of patients. Thus, this study aimed to identify whether Piezo1 may become a new prognostic biomarker for glioma patients.

Patients and methods

Firstly, Piezo1 expression of gliomas was analyzed through GEO and Oncomine dataset, and verified by qRT-PCR and immunohistochemistry (IHC) methods. A total of 183 glioma patients were included in this study between January 2010 and December 2014. Kaplan-Meier survival analyses, Cox regression analyses and ROC curve analyses were performed to assess the diagnostic and prognostic values of Piezo1 in glioma patients.

Results

In this

SUBMITTER: Qu S 

PROVIDER: S-EPMC7244349 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature