Preimplantation genetic testing for aneuploidy in poor ovarian responders with four or fewer oocytes retrieved.

ABSTRACT:

Purpose

To assess whether preimplantation genetic testing for aneuploidies (PGT-A) at the blastocyst stage improves clinical outcomes compared with transfer of embryos without PGT-A in poor ovarian response (POR) patients.

Methods

Retrospective cohort study of IVF cycles from 2016 to 2019 at a single academic fertility center. IVF cycles with POR and four or fewer oocytes retrieved were stratified into PGT-A (n = 241) and non-PGT (n = 112) groups. In PGT-A cycles, trophectoderm biopsy, next-generation sequencing with 24-chromosome screening, and single euploid frozen embryo transfer were performed. In non-PGT cycles, fresh or frozen transfer of untested embryos on day 3 or 5 was performed. Main outcomes included live birth rate and miscarriage rate per retrieval.

Result(s

SUBMITTER: Deng J 

PROVIDER: S-EPMC7244670 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature