Impact of progestin ovarian stimulation on newborn outcomes: a meta-analysis.

ABSTRACT:

Objectives

To compare progestin ovarian stimulation protocols with gonadotropin-releasing hormone analogue (agonists and antagonists) protocols on newborn outcomes.

Methods

The PubMed, Embase, Cochrane Central Register of Controlled Trials, and BioMed Central databases were searched for studies comparing progestin prime ovarian stimulation (PPOS) protocols with gonadotropin-releasing hormone analogues. Data were pooled by meta-analysis using a random effects model.

Main outcome measures

Primary endpoint was the risk of newborn congenital malformations.

Results

A total of 4 studies involving 9274 live-born infants were included. No important harm was observed with PPOS in terms of congenital malformations (OR 0.92; 95% CI 0.63-1.34; p = 0.65) (very low quality o

SUBMITTER: Zolfaroli I 

PROVIDER: S-EPMC7244671 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature