Antidiabetic drug metformin affects the developmental competence of cleavage-stage embryos.

ABSTRACT:

Purpose

Metformin is the most commonly prescribed drug in the management of metabolic disorders such as polycystic ovarian syndrome (PCOS) and gestational diabetes in women of reproductive age. Insulin-sensitizing effect of metformin helps in improving from PCOS features such as hyperandrogenism, anovulation, and infertility. However, its ability to cross placental barrier raises concern about safety of the drug on early embryonic development. In this study, we evaluated the effect of metformin on the ovarian function and embryo development.

Methods

Adult Swiss albino female mice were administered with metformin (0, 50, 100, and 200 mg/kg body weight) for 4 weeks and assessed for reproductive function and preimplantation embryo development. Further, effect of metformin (0, 1

SUBMITTER: Nayak G 

PROVIDER: S-EPMC7244706 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature