The high efficacy of luliconazole against environmental and otomycosis Aspergillus flavus strains.

ABSTRACT:

Background and objectives

Luliconazole is currently confirmed for the topical therapy of dermatophytosis. Moreover, it is found that luliconazole has in vitro activity against some molds and yeast species. The aim of the present study was to evaluate the efficacy of luliconazole in comparison to routine used antifungals on clinical and environmental isolates of Aspergillus flavus.

Materials and methods

Thirty eight isolates of A. flavus (18 environmental and 20 clinical isolates) were detected based on morphological and microscopic features and also PCR-sequencing of β-tubulin ribosomal DNA gene. All the isolates were tested against luliconazole, voriconazole, amphotericin B and caspofungin. Minimum inhibitory concentration (MIC), MIC₅₀, MIC

SUBMITTER: Moslem M 

PROVIDER: S-EPMC7244823 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature