Dataset Information

MitraClip^® as bridging strategy for heart transplantation in Chagas cardiomyopathy: a case report.

ABSTRACT:

Background

Patients with end-stage heart failure, suffering from severe pulmonary hypertension (PH) and elevated pulmonary vascular resistance, are not eligible for heart transplant due to high mortality risk and primary graft dysfunction. Severe PH may be favoured by functional severe mitral regurgitation, which is present in many cardiopathies like end-stage Chagasic cardiomyopathy.

Case summary

We present a case of a young man with end-stage heart failure secondary to Chagas cardiomyopathy with severe functional mitral regurgitation (FMR) and severe PH. The patient received percutaneous correction with MitraClip® system reducing PH and making him a suitable candidate for heart transplant.

Discussion

In patients with advanced heart failure, FMR, and severe PH, optimal treatment according to current guide lines is recommended. MitraClip^® therapy appears to be safe and effective for control of severe PH as a bridge measure for cardiac transplantation.

SUBMITTER: Vasquez-Rodriguez JF

PROVIDER: S-EPMC7245051 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

MitraClip<sup>®</sup> as bridging strategy for heart transplantation in Chagas cardiomyopathy: a case report.

Vasquez-Rodríguez Juan Felipe JF Medina Héctor Manuel HM Cabrales Jaime Ramón JR Torres Adriana Gisella AG

European heart journal. Case reports 20200118 1

<h4>Background</h4>Patients with end-stage heart failure, suffering from severe pulmonary hypertension (PH) and elevated pulmonary vascular resistance, are not eligible for heart transplant due to high mortality risk and primary graft dysfunction. Severe PH may be favoured by functional severe mitral regurgitation, which is present in many cardiopathies like end-stage Chagasic cardiomyopathy.<h4>Case summary</h4>We present a case of a young man with end-stage heart failure secondary to Chagas ca ...[more]

PMID: 32467867

Similar Datasets

Project description:BackgroundTranscatheter mitral valve repair (TMVR) has been shown to have acute effects on mitral valve geometry in patients with functional mitral regurgitation (FMR). This study investigates the impact of MitraClip® therapy-induced annular remodeling on clinical outcome and mitral regurgitation in heart failure patients.MethodsTMVR was performed successfully in 45 patients with FMR. In this study, mitral valve datasets were obtained before and directly after MitraClip® implantation using three-dimensional (3D) transesophageal echocardiography, and were analyzed offline retrospectively using dedicated 3D reconstruction software. Patients underwent clinical and echocardiographic evaluation at baseline and after 6 months. At follow-up, the patients were allocated into two groups according to their improvement in New York Heart Association (NYHA) functional class: a Low Responder group with ΔNYHA <1.5 (n = 25); and a High Responder group with ΔNYHA ≥1.5 (n = 20).ResultsAt 6-month follow-up, data analysis revealed that while mitral regurgitation was reduced significantly in both groups, only the High Responder group had experienced significant downsizing of the 3D circumference (137 ± 14 mm to 126 ± 13 mm; p < 0.01) and the anterior-to-posterior diameter (33 ± 5 mm to 29 ± 4 mm; p < 0.01) of the mitral annulus during the intervention. Furthermore, only the High Responder group with reverse annular remodeling as shown had substantial advances in quality of life (Minnesota living with heart failure questionnaire: 55 ± 10 to 34 ± 14 points; p < 0.01) and functional status (6-min walk distance: 290 ± 104 m to 462 ± 111 m; p = 0.07).ConclusionOur study demonstrates that instantaneous left ventricular annular remodeling during MitraClip® implantation is associated with improved clinical outcome of heart failure patients with functional mitral regurgitation. Trial registration The study was approved by the local ethics committee (Study Number 4497R, Registration ID: 2013121585).Trial registrationNCT02033811 Retrospectively registered January 9, 2014.

Dataset Information

MitraClip^® as bridging strategy for heart transplantation in Chagas cardiomyopathy: a case report.

Background

Case summary

Discussion

Publications

MitraClip<sup>®</sup> as bridging strategy for heart transplantation in Chagas cardiomyopathy: a case report.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

MitraClip® as bridging strategy for heart transplantation in Chagas cardiomyopathy: a case report.

Background

Case summary

Discussion

Publications

MitraClip<sup>®</sup> as bridging strategy for heart transplantation in Chagas cardiomyopathy: a case report.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

MitraClip^® as bridging strategy for heart transplantation in Chagas cardiomyopathy: a case report.