Antiepileptic drugs induce subcritical dynamics in human cortical networks.

ABSTRACT: Cortical network functioning critically depends on finely tuned interactions to afford neuronal activity propagation over long distances while avoiding runaway excitation. This importance is highlighted by the pathological consequences and impaired performance resulting from aberrant network excitability in psychiatric and neurological diseases, such as epilepsy. Theory and experiment suggest that the control of activity propagation by network interactions can be adequately described by a branching process. This hypothesis is partially supported by strong evidence for balanced spatiotemporal dynamics observed in the cerebral cortex; however, evidence of a causal relationship between network interactions and cortex activity, as predicted by a branching process, is missing in humans. Here th

SUBMITTER: Meisel C 

PROVIDER: S-EPMC7245074 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature