The role of the Arp2/3 complex in shaping the dynamics and structures of branched actomyosin networks.

ABSTRACT: Actomyosin networks give cells the ability to move and divide. These networks contract and expand while being driven by active energy-consuming processes such as motor protein walking and actin polymerization. Actin dynamics is also regulated by actin-binding proteins, such as the actin-related protein 2/3 (Arp2/3) complex. This complex generates branched filaments, thereby changing the overall organization of the network. In this work, the spatiotemporal patterns of dynamical actin assembly accompanying the branching-induced reorganization caused by Arp2/3 were studied using a computational model (mechanochemical dynamics of active networks [MEDYAN]); this model simulates actomyosin network dynamics as a result of chemical reactions whose rates are modulated by rapid mechanical equilibrat

SUBMITTER: Liman J 

PROVIDER: S-EPMC7245093 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature