Seizure pathways change on circadian and slower timescales in individual patients with focal epilepsy.

ABSTRACT: Personalized medicine requires that treatments adapt to not only the patient but also changing factors within each individual. Although epilepsy is a dynamic disorder characterized by pathological fluctuations in brain state, surprisingly little is known about whether and how seizures vary in the same patient. We quantitatively compared within-patient seizure network evolutions using intracranial electroencephalographic (iEEG) recordings of over 500 seizures from 31 patients with focal epilepsy (mean 16.5 seizures per patient). In all patients, we found variability in seizure paths through the space of possible network dynamics. Seizures with similar pathways tended to occur closer together in time, and a simple model suggested that seizure pathways change on circadian and/or slower timesc

SUBMITTER: Schroeder GM 

PROVIDER: S-EPMC7245106 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature