Serum miR-182 is a predictive biomarker for dichotomization of risk of hepatocellular carcinoma in rats.

ABSTRACT: Exploration of animal models leads to discoveries that can reveal candidate biomarkers for translation to human populations. Herein, a model of hepatocarcinogenesis and protection was used in which rats treated with aflatoxin (AFB₁ ) daily for 28 days (200 µg/kg BW) developed tumors compared with rats completely protected from tumors by concurrent administration of the chemoprotective agent, 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im). Differential expression of miRNAs in tumors (AFB₁ ) and nontumor (AFB₁  + CDDO-Im) bearing livers and their levels in sera over the life-course of the animals was determined. miRNA transcriptome analysis identified 17 miRNAs significantly upregulated at greater than five-fold in the tumors. The ten mo

SUBMITTER: Livingstone MC 

PROVIDER: S-EPMC7245160 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature