Adherence to oral anticoagulants among patients with atrial fibrillation: a systematic review and meta-analysis of observational studies.

ABSTRACT:

Introduction

Medications cannot exert their effect if not taken as prescribed by patients. Our objective was to summarise the observational evidence on adherence to oral anticoagulants (OACs) among patients with atrial fibrillation (AF).

Methods

In March 2019, we systematically searched PubMed/Medline, Embase, CINAHL and PsycINFO (from inception) for observational studies measuring adherence, its determinants and impacts in patients with AF. Mean adherence measures and corresponding proportions of adherent patients were pooled using random effects models. Factors shown to be independently associated with adherence were extracted as well as the clinical and economic outcomes of adherence.

Results

We included 30 studies. Pooled mean adherence scores of over half a milli

SUBMITTER: Salmasi S 

PROVIDER: S-EPMC7245382 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature