Insulin enhances renal glucose excretion: relation to insulin sensitivity and sodium-glucose cotransport.

ABSTRACT:

Introduction

Insulin regulates renal glucose production and utilization; both these fluxes are increased in type 2 diabetes (T2D). Whether insulin also controls urinary glucose excretion is not known.

Methods

We applied the pancreatic clamp technique in 12 healthy subjects and 13 T2D subjects. Each participant received a somatostatin infusion and a variable glucose infusion to achieve (within 1 hour) and maintain glycemia at 22 mmol/L for 3 hours; next, a constant insulin infusion (240 pmol/min/kg) was added for another 3 hours. Urine was collected separately in each period for glucose and creatinine determination.

Results

During saline, glucose excretion was lower in T2D than controls in absolute terms (0.49 (0.32) vs 0.69 (0.18) mmol/min, median (IQR), p=0.01) and a

SUBMITTER: Ferrannini E 

PROVIDER: S-EPMC7245398 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature