Soluble CD14 and Risk of Heart Failure and Its Subtypes in Older Adults.

ABSTRACT:

Background

CD14 is a membrane glycoprotein primarily expressed by myeloid cells that plays a key role in inflammation. Soluble CD14 (sCD14) levels carry a poor prognosis in chronic heart failure (HF), but whether elevations in sCD14 precede HF is unknown. We tested the hypothesis that sCD14 is associated with HF incidence and its subtypes independent of major inflammatory biomarkers among older adults.

Methods and results

We included participants in the Cardiovascular Health Study without preexisting HF and available baseline sCD14. We evaluated the associations of sCD14, high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, and white blood cell count (WBC) with incident HF and subtypes using Cox regression. Among 5217 participants, 1878 had incident HF over 13.6

SUBMITTER: Al-Kindi SG 

PROVIDER: S-EPMC7245550 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature