Trend analysis of tuberculosis case notifications with scale-up of antiretroviral therapy and roll-out of isoniazid preventive therapy in Zimbabwe, 2000-2018.

ABSTRACT:

Objectives

Antiretroviral therapy (ART) and isoniazid preventive therapy (IPT) are known to have a tuberculosis (TB) protective effect at the individual level among people living with HIV (PLHIV). In Zimbabwe where TB is driven by HIV infection, we have assessed whether there is a population-level association between IPT and ART scale-up and annual TB case notification rates (CNRs) from 2000 to 2018.

Design

Ecological study using aggregate national data.

Setting

Annual aggregate national data on TB case notification rates (stratified by TB category and type of disease), numbers (and proportions) of PLHIV in ART care and of these, numbers (and proportions) ever commenced on IPT.

Results

ART coverage in the public sector increased from <1% (8400 PLHIV) in 2004 to

SUBMITTER: Takarinda KC 

PROVIDER: S-EPMC7245618 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature