Underdiagnoses of Rickettsia in patients hospitalized with acute fever in Indonesia: observational study results.

ABSTRACT:

Background

Reports of human rickettsial infection in Indonesia are limited. This study sought to characterize the epidemiology of human rickettsioses amongst patients hospitalized with fever at 8 tertiary hospitals in Indonesia.

Methods

Acute and convalescent blood from 975 hospitalized non-dengue patients was tested for Rickettsia IgM and IgG by ELISA. Specimens from cases with seroconversion or increasing IgM and/or IgG titers were tested for Rickettsia IgM and IgG by IFA and Rickettsia genomes using primers for Rickettsia (R.) sp, R. typhi, and Orientia tsutsugamushi. Testing was performed retrospectively on stored specimens; results did not inform patient management.

Results

R. typhi, R. rickettsii, and O. tsutsugamushi IgG antibodies were identified in 269/872 (3

SUBMITTER: Lokida D 

PROVIDER: S-EPMC7245627 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature