Preconditioning is an effective strategy for improving the efficiency of mesenchymal stem cells in kidney transplantation.

ABSTRACT: The inevitable side effects caused by lifelong immunosuppressive agents in kidney transplantation patients spurred the exploration of novel immunosuppressive strategies with definite curative effects and minimal adverse effects. Mesenchymal stem cells (MSCs) have become a promising candidate due to their role in modulating the immune system. Encouraging results obtained from experimental models have promoted the translation of this strategy into clinical settings. However, the demonstration of only marginal or transient benefits by several recent clinical controlled studies has made physicians hesitant to adopt the routine utilization of this procedure in clinical settings. Impaired MSC function after infusion in vivo was thought to be the main reason for their limited effects. For this re

SUBMITTER: Zhao L 

PROVIDER: S-EPMC7245776 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature