Identification of a new effector-immunity pair of Aeromonas hydrophila type VI secretion system.

ABSTRACT: The type VI secretion system (T6SS) is a multiprotein weapon that kills eukaryotic predators or prokaryotic competitors by delivering toxic effectors. Despite the importance of T6SS in bacterial environmental adaptation, it is still challenging to systematically identify T6SS effectors because of their high diversity and lack of conserved domains. In this report, we discovered a putative effector gene, U876-17730, in the whole genome of Aeromonas hydrophila NJ-35 based on the reported conservative domain DUF4123 (domain of unknown function), with two cognate immunity proteins encoded downstream. Phylogenetic tree analysis of amino acids indicates that AH17730 belongs to the Tle1 (type VI lipase effector) family, and therefore was named Tle1^AH. The deletion of tle1^AH r

SUBMITTER: Ma S 

PROVIDER: S-EPMC7245790 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature