Improvement in circulating endothelial progenitor cells pool after cardiac resynchronization therapy: increasing the list of benefits.

ABSTRACT:

Background

Recent studies suggest that circulating endothelial progenitor cells (EPCs) may influence the response to cardiac resynchronization therapy (CRT). The aim of this study was to evaluate the effect of CRT on EPC levels and to assess the impact of EPCs on long-term clinical outcomes.

Population and methods

Prospective study of 50 patients submitted to CRT. Two populations of circulating EPCs were quantified previously to CRT implantation: CD34⁺KDR⁺ and CD133⁺KDR⁺ cells. EPC levels were reassessed 6 months after CRT. Endpoints during the long-term follow-up were all-cause mortality, heart transplantation, and hospitalization for heart failure (HF) management.

Results

The proportion of non-responders to CRT was 42% and

SUBMITTER: Cristovao G 

PROVIDER: S-EPMC7245793 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature