RNA-binding protein MSI2 isoforms expression and regulation in progression of triple-negative breast cancer.

ABSTRACT:

Background

The RNA-binding protein Musashi-2 (MSI2) has been implicated in the tumorigenesis and tumor progression of some human cancers. MSI2 has also been reported to suppress tumor epithelial-to-mesenchymal transition (EMT) progression in breast cancer, and low MSI2 expression is associated with poor outcomes for breast cancer patients; however, the underlying mechanisms have not been fully investigated. This study investigated the expression and phenotypic functions of two major alternatively spliced MSI2 isoforms (MSI2a and MSI2b) and the potential molecular mechanisms involved in triple-negative breast cancer (TNBC) progression.

Methods

The Illumina sequencing platform was used to analyze the mRNA transcriptomes of TNBC and normal tissues, while quantitative reverse tr

SUBMITTER: Li M 

PROVIDER: S-EPMC7245804 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature