Aligning functional network constraint to evolutionary outcomes.

ABSTRACT: BACKGROUND:Functional constraint through genomic architecture is suggested to be an important dimension of genome evolution, but quantitative evidence for this idea is rare. In this contribution, existing evidence and discussions on genomic architecture as constraint for convergent evolution, rapid adaptation, and genic adaptation are summarized into alternative, testable hypotheses. Network architecture statistics from protein-protein interaction networks are then used to calculate differences in evolutionary outcomes on the example of genomic evolution in yeast, and the results are used to evaluate statistical support for these longstanding hypotheses. RESULTS:A discriminant function analysis lent statistical support to classifying the yeast interactome into hub, intermediate and periphe

SUBMITTER: Wollenberg Valero KC 

PROVIDER: S-EPMC7245893 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature