Metabolomic fingerprinting and systemic inflammatory profiling of asthma COPD overlap (ACO).

ABSTRACT:

Background

Asthma-COPD overlap (ACO) refers to a group of poorly studied and characterised patients reporting with disease presentations of both asthma and COPD, thereby making both diagnosis and treatment challenging for the clinicians. They exhibit a higher burden in terms of both mortality and morbidity in comparison to patients with only asthma or COPD. The pathophysiology of the disease and its existence as a unique disease entity remains unclear. The present study aims to determine whether ACO has a distinct metabolic and immunological mediator profile in comparison to asthma and COPD.

Methods

Global metabolomic profiling using two different groups of patients [discovery (D) and validation (V)] were conducted. Serum samples obtained from moderate and severe asthma [n =

SUBMITTER: Ghosh N 

PROVIDER: S-EPMC7245917 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature