Novel visualized quantitative epigenetic imprinted gene biomarkers diagnose the malignancy of ten cancer types.

ABSTRACT:

Background

Epigenetic alterations are involved in most cancers, but its application in cancer diagnosis is still limited. More practical and intuitive methods to detect the aberrant expressions from clinical samples using highly sensitive biomarkers are needed. In this study, we developed a novel approach in identifying, visualizing, and quantifying the biallelic and multiallelic expressions of an imprinted gene panel associated with cancer status. We evaluated the normal and aberrant expressions measured using the imprinted gene panel to formulate diagnostic models which could accurately distinguish the imprinting differences of normal and benign cases from cancerous tissues for each of the ten cancer types.

Results

The Quantitative Chromogenic Imprinted Gene In Situ Hybrid

SUBMITTER: Shen R 

PROVIDER: S-EPMC7245932 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature