The Genome Structure of Ciprofloxacin-Resistant Mycoplasma Hominis Clinical Isolates.

ABSTRACT: The genome structure of three ciprofloxacin-resistant Mycoplasma hominis clinical isolates was studied using next-generation sequencing on the Illumina platform. The protein sequences of the studied Mycoplasma strains were found to have a high degree of homology. Mycoplasma hominis (M45, M57, MH1866) was shown to have limited biosynthetic capabilities, associated with the predominance of the genes encoding the proteins involved in catabolic processes. Multiple single-nucleotide substitutions causing intraspecific polymorphism of Mycoplasma hominis were found. The genes encoding the efflux systems - ABC transporters (the ATP-binding cassette superfamily) and proteins of the MATE (multidrug and toxic compound extrusion) family - were identified. The molecular mechanism of ciprofloxacin resis

SUBMITTER: Kolesnikova EA 

PROVIDER: S-EPMC7245959 | biostudies-literature | 2020 Jan-Mar

REPOSITORIES: biostudies-literature