Bioinformatics analyses of retinoblastoma reveal the retinoblastoma progression subtypes.

ABSTRACT:

Introduction

Retinoblastoma (RB) is one common pediatric malignant tumor with dismal outcomes. Heterogeneity of RB and subtypes of RB were identified but the association between the subtypes of RB and RB progression have not been fully investigated.

Methods

Four public datasets were downloaded from Gene expression omnibus and normalization was performed to remove batch effect. Two public datasets were explored to obtain the RB progression gene signatures by differentially expression analysis while another two datasets were iterated for RB subtypes identification using consensus clustering. After the RB progressive subtype gene signatures were identified, we tested the diagnostic capacity of these gene signatures by receiver operation curve.

Results

Three hundreds and

SUBMITTER: Cao M 

PROVIDER: S-EPMC7246025 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature