Long-Term Functional Outcomes Among Childhood Survivors of Cancer Who Have a History of Osteonecrosis.

ABSTRACT:

Background

Glucocorticoids used to treat childhood leukemia and lymphoma can result in osteonecrosis, leading to physical dysfunction and pain. Improving survival rates warrants research into long-term outcomes among this population.

Objective

The objective of this study was to compare the physical function and quality of life (QOL) of survivors of childhood cancer who had an osteonecrosis history with that of survivors who had no osteonecrosis history and with that of people who were healthy (controls).

Design

This was a cross-sectional study.

Methods

This study included St Jude Lifetime Cohort Study participants who were ≥ 10 years from the diagnosis of childhood leukemia or lymphoma and ≥ 18 years old; 135 had osteonecrosis (52.5% men; mean age = 27.7 [SD = 

SUBMITTER: DeFeo BM 

PROVIDER: S-EPMC7246066 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature