Incidence of Macular Atrophy after Untreated Neovascular Age-Related Macular Degeneration: Age-Related Eye Disease Study Report 40.

ABSTRACT:

Purpose

To report the natural history of untreated neovascular age-related macular degeneration (nAMD) regarding subsequent macular atrophy.

Design

Prospective cohort within a randomized, controlled trial of oral micronutrient supplements.

Participants

Age-Related Eye Disease Study (AREDS) participants (55-80 years) who demonstrated nAMD during follow-up (1992-2005), prior to anti-vascular endothelial growth factor (VEGF) therapy.

Methods

Color fundus photographs were collected at annual study visits and graded centrally for late age-related macular degeneration (AMD). Incident macular atrophy after nAMD was examined by Kaplan-Meier analysis and proportional hazards regression.

Main outcome measures

Incident macular atrophy after nAMD.

Results

Of

SUBMITTER: Christakis PG 

PROVIDER: S-EPMC7246151 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature