Assessment of femoral neck bone metabolism using ¹⁸F-sodium fluoride PET/CT imaging.

ABSTRACT:

Background

Standard of care metabolic bone disease assessment relies on changes to bone quantity, which can only be detected after structural changes occur.

Purpose

To investigate the usefulness of Bone Metabolism Score (BMS), derived from fluorine 18 labeled sodium fluoride (¹⁸F-NaF) PET/CT imaging as a biomarker of localized metabolic changes at the femoral neck.

Methods

In this retrospective study, 139 participants (68 females and 71 males, ages 21-75 years) that had undergone ¹⁸F-NaF PET/CT were included. BMS was calculated as the ratio of standard uptake value (SUV) in the bone region to that of the total region. Correlations and linear regressions of BMS with age, CT-derived bone mineral density (BMD), body mass index (BMI), height, and wei

SUBMITTER: Rhodes S 

PROVIDER: S-EPMC7246165 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature