6-Deoxy- and 11-Hydroxytolypodiols: Meroterpenoids from the Cyanobacterium HT-58-2.

ABSTRACT: Chemical investigation of cyanobacterial strain HT-58-2, which most closely aligns with the genus Brasilomena, has led to the isolation of two compounds related to tolypodiol. The structures and absolute configuration of 6-deoxytolypodiol (1) and 11-hydroxytolypodiol (2) were elucidated by spectroscopic and spectrometric analysis. While tolypodiol previously showed anti-inflammatory activity in a mouse ear edema assay, only 2 reduced in vitro thromboxane B₂ and superoxide anion (O₂^-) generation from Escherichia coli lipopolysaccharide-activated rat neonatal microglia to any appreciable degree.

SUBMITTER: Gurr JR 

PROVIDER: S-EPMC7246299 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature