Intact myocardial preparations reveal intrinsic transmural heterogeneity in cardiac mechanics.

ABSTRACT: Determining transmural mechanical properties in the heart provides a foundation to understand physiological and pathophysiological cardiac mechanics. Although work on mechanical characterisation has begun in isolated cells and permeabilised samples, the mechanical profile of living individual cardiac layers has not been examined. Myocardial slices are 300 μm-thin sections of heart tissue with preserved cellular stoichiometry, extracellular matrix, and structural architecture. This allows for cardiac mechanics assays in the context of an intact in vitro organotypic preparation. In slices obtained from the subendocardium, midmyocardium and subepicardium of rats, a distinct pattern in transmural contractility is found that is different from that observed in other models. Slices from the epica

SUBMITTER: Pitoulis FG 

PROVIDER: S-EPMC7246333 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature