Investigation of Heartland Virus Disease Throughout the United States, 2013-2017.

ABSTRACT:

Background

Heartland virus (HRTV) was first described as a human pathogen in 2012. From 2013 to 2017, the Centers for Disease Control and Prevention (CDC) implemented a national protocol to evaluate patients for HRTV disease, better define its geographic distribution, epidemiology, and clinical characteristics, and develop diagnostic assays for this novel virus.

Methods

Individuals aged ≥12 years whose clinicians contacted state health departments or the CDC about testing for HRTV infections were screened for recent onset of fever with leukopenia and thrombocytopenia. A questionnaire was administered to collect data on demographics, risk factors, and signs and symptoms; blood samples were tested for the presence of HRTV RNA and neutralizing antibodies.

Results

Of 85 i

SUBMITTER: Staples JE 

PROVIDER: S-EPMC7246346 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature