Relevance research between the expression of p16^INK4a , Notch1, and hTERC genes: The development of HPV16-positive cervical cancer.

ABSTRACT:

Background

GLOBOCAN 2018 latest data show cervical cancer ranks fourth in morbidity and mortality among women. Many genes in cervical lesions differ in sensitivity and specificity. However, the diagnostic molecules for early cervical cancer are not very clear. This paper screens biomarkers for early molecular diagnosis of Mongolian patients with cervical cancer.

Methods

Immunohistochemical SP method was used to detect the expression of p16^INK4a and Notch1 protein in paraffin sections of 226 Mongolian patients with HPV16-positive cervical lesions after pathological examination, and 100 of them were randomly selected by fluorescence in situ hybridization to detect hTERC gene. The HPV16-binding human cervical cancer SiHa cell line was used to silence the expression o

SUBMITTER: Huo W 

PROVIDER: S-EPMC7246350 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature