Association of the genetic variants (-794 CATT5-8 and -173 G > C) of macrophage migration inhibitory factor (MIF) with higher soluble levels of MIF and TNFα in women with breast cancer.

ABSTRACT:

Background

Functional variants -173 G > C (rs755622) and -794CATT_5-8 (rs5844572) MIF gene have been associated with the risk in several types of cancer, as well as with the increase of soluble levels of MIF and TNFα. However, in previous studies contradictory and uncertain results have been presented on the implication of MIF polymorphisms with the association in cancer, specifically in breast cancer (BC). We investigated whether the variants are associated with the susceptibility to develop BC and the soluble levels of MIF and TNFα in women with BC from western Mexico.

Materials and methods

A total of 152 women with BC and 182 control subjects (CS) were enrolled in this study. The determination of genotypes -173 G > C and -794 CATT_5-8 MIF polymorphisms

SUBMITTER: Avalos-Navarro G 

PROVIDER: S-EPMC7246356 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature