Function and regulation annotation of up-regulated long non-coding RNA LINC01234 in gastric cancer.

ABSTRACT:

Background

Accumulated evidences indicate that long non-coding RNAs (lncRNAs) participate in many biological mechanisms. Moreover, it acts as an essential regulator in various human diseases such as gastric cancer (GC). Nevertheless, the comprehensive regulatory roles and clinical significance of most lncRNAs in GC are not fully understood.

Methods

In this research, our aim was to investigate the underlying mechanism of lncRNA LINC01234 in GC. Firstly, the usage of qRT-PCR helped to establish expression pattern of LINC01234 in GC tissues. Following this, appropriate statistical tests were applied to analyze the relation between expression level and clinicopathological factors. Ultimately, potential functions and regulatory network of LINC01234 were concluded via GSEA and a s

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC7246363 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature