Novel classifiers with clinical laboratory parameters for early detection of osteosarcoma.

ABSTRACT:

Background

Osteosarcoma (OS) is one of the most common malignant bone tumors. It is essential to explore early diagnostic indicators with high sensitivity and specificity due to the rapid progression and metastasis of OS and the poor survival of metastatic OS patients. However, a few indicators of diagnostic significance have been described.

Methods

A total of 458 OS patients, 312 healthy individuals, and 228 patients with primary benign bone lesions were included. Logistic regression was performed on 46 clinical laboratory parameters to establish the diagnostic classifiers, which were evaluated by analysis of the receiver operating characteristic (ROC) curves.

Results

We established three diagnostic classifiers, called C_os for all ages, C_los for

SUBMITTER: Cao LL 

PROVIDER: S-EPMC7246378 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature