TBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate.

ABSTRACT: Nutritional status, in particular overweight and obesity, as well as sedentarism and high-fat diet consumption, are important risk factors to develop chronic diseases, which have a higher impact on the elderly's health. Therefore, these nutritional problems have become a concern to human healthspan and longevity. The fatty acids obtained thru the diet or due to fatty acid synthesis during obesity accumulate within the body generating toxicity and cell death. Fat is not only stored in adipose tissue, but it can also be stored in skeletal muscle. Palmitic acid (PA) has been reported as one of the most important saturated free fatty acids; it is associated to chronic oxidative stress and increased mitochondrial ROS production causing cell death by apoptosis. In skeletal muscle, palmitate has

SUBMITTER: Posadas-Rodriguez P 

PROVIDER: S-EPMC7246405 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature