Targeting AKT/mTOR in Oral Cancer: Mechanisms and Advances in Clinical Trials.

ABSTRACT: Oral cancer (OC) is a devastating disease that takes the lives of lots of people globally every year. The current spectrum of treatment modalities does not meet the needs of the patients. The disease heterogeneity demands personalized medicine or targeted therapies. Therefore, there is an urgent need to identify potential targets for the treatment of OC. Abundant evidence has suggested that the components of the protein kinase B (AKT)/ mammalian target of rapamycin (mTOR) pathway are intrinsic factors for carcinogenesis. The AKT protein is central to the proliferation and survival of normal and cancer cells, and its downstream protein, mTOR, also plays an indispensable role in the cellular processes. The wide involvement of the AKT/mTOR pathway has been noted in oral squamous cell carcinom

SUBMITTER: Harsha C 

PROVIDER: S-EPMC7246494 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature